TMG, short for trimethylglycine, might sound like something out of science fiction, but it’s a naturally occurring substance your body can even make on its own. You might also see it called betaine or betaine anhydrous.

Think of TMG as a multi-tasking molecule with a few key jobs. One of its important roles is in liver function and helping your body process an amino acid called homocysteine. Homocysteine is like a double-edged sword. We need it, but too much can be bad for heart and brain health. TMG helps keep homocysteine levels in check.

TMG (Trimethylglycine) Tablets

TMG is also an osmolyte, a fancy word for a molecule that helps your cells regulate their water balance. Imagine your cells as tiny balloons – TMG helps them stay plump and healthy by keeping the right amount of fluid inside.

On top of that, TMG is involved in methylation, a crucial cellular process for DNA production and other functions.

TMG can be found in some foods like beets, spinach, and quinoa, but you can also take it as a supplement.


What are TMG supplements used for?

TMG supplements are being looked at for a few different reasons, though it’s important to note the research is still ongoing. Here are some of the potential benefits people are interested in:

Heart Health

As mentioned before, TMG helps regulate homocysteine levels, and high homocysteine is linked to an increased risk of heart disease. So, some people take TMG supplements hoping to keep their heart healthy.

Athletic Performance

Some athletes take TMG to potentially boost their performance. The idea is that TMG might help with fatigue, increase protein production, and even aid in the creation of creatine, which fuels muscles.

Blood Sugar Control

There’s early research suggesting TMG might improve insulin sensitivity, which helps your body use blood sugar more effectively. This could be of interest to people with conditions like insulin resistance or prediabetes.

It’s important to remember that these are just potential benefits, and more studies are needed to confirm how effective TMG supplements are for these purposes.


What are the benefits of taking TMG supplements?

Heart Health Hero

TMG might be a teammate for your heart. It helps keep homocysteine levels in check, and high homocysteine is like a red flag for heart health. By potentially lowering homocysteine, TMG could be a player in reducing the risk of heart disease.


Athletic Advantage (Maybe)

Some athletes are turning to TMG for a potential performance boost. The idea is that TMG might help fight fatigue, allowing you to train harder for longer. It might also play a role in building muscle and increasing creatine production, which fuels your workouts. However, the research is still young on this one.


Blood Sugar Balancing Act

Early studies suggest TMG could help your body use blood sugar more efficiently. This could be beneficial for people with conditions like insulin resistance or prediabetes, where the body struggles to manage blood sugar levels.

TMG Trimethylglycine

Are there any side effects to TMG supplements?

TMG supplements are generally considered safe for most people, but there can be some downsides to be aware of:

Belly Blues

The most common side effects are digestive issues like diarrhea, nausea, bloating, and cramps. These usually happen when you take a high dose. If you experience these, try lowering the dosage or taking it with food to see if it helps.

Methionine Mischief (Rare)

In rare cases, high doses of TMG can significantly increase methionine levels in the blood. Methionine is another amino acid, and too much of it can be problematic. This is especially important to consider if you have a genetic condition called homocystinuria.

Body Odor Boost (Uncommon)

Some people report a slight increase in body odor after taking TMG supplements. This is likely due to changes in gut bacteria and is usually temporary.

Pregnant and breastfeeding women, children,
and people with kidney disease should avoid TMG supplements unless advised by a doctor.

Supplement Showdown: TMG can interact with certain medications, so talk to your doctor before starting TMG if you’re already taking something else.

Moleclar TMG tablets

What is a safe dosage of TMG supplements?

Figuring out the right dosage of TMG supplements can feel like navigating a maze. There’s no one-size-fits-all answer, and it can depend on several factors:

Your Goals

Are you taking TMG for general health or a specific concern? This can influence the recommended dosage.

Your Body

Factors like weight and overall health can play a role.

The Supplement Itself

Different TMG supplements come in varying strengths, so check the label carefully.

Here’s a general guideline to get you started:

Low Dose (500mg – 1,000mg daily)

This is a good starting point for most people and might be suitable for general health support.

Moderate Dose (1,000mg – 3,000mg daily)

This range is often used for specific goals like improving athletic performance or managing homocysteine levels.

Lower supplements

Who should consider taking TMG supplements?

TMG supplements might be worth considering for a few different groups of people:

The Heart-Conscious Crew

If you’re concerned about heart health and have high homocysteine levels, TMG could be a potential teammate. By helping to regulate homocysteine, it might contribute to a healthier heart. However, it’s important to discuss this with your doctor, as there might be other underlying factors affecting your heart health.


The Fitness Fanatics (Looking for an Edge)

Some athletes are exploring TMG for a possible performance boost. The idea is that TMG might help fight fatigue, improve muscle building, and even aid in creatine production, all contributing to a more powerful workout. But remember, the research on this is still developing.


The Blood Sugar Balancing Seekers

 Early studies suggest TMG might improve how your body uses blood sugar. This could be of interest to people with conditions like insulin resistance or prediabetes, where the body struggles to manage blood sugar effectively. However, it’s not a magic bullet, and consulting your doctor is key before trying TMG.


What foods are naturally high in TMG?

While TMG supplements are available, you might be surprised to learn that you can also get this interesting molecule from some everyday foods! Here’s a rundown of some TMG champions:

Leafy Green All-Stars: Popeye wasn’t wrong about spinach! Leafy greens like spinach, kale, and Swiss chard are powerhouses of various nutrients, and TMG is one of them.

Quinoa – The Mighty Seed: This ancient grain isn’t just a protein powerhouse; it’s also a good source of TMG.

Beetroot – The Earthy Delight: Don’t underestimate the humble beet! This veggie packs a surprising amount of TMG, adding an earthy twist to your TMG intake.

Wheat Bran – The Fiber Friend: Wheat bran, the outer layer of the wheat kernel, is high in fiber and, you guessed it, TMG!

Wheat Germ – The Hidden Treasure: Wheat germ, the heart of the wheat kernel, is another source of TMG and other nutrients, although it’s not as commonly consumed as wheat bran.


How does TMG work in the body?

TMG works in your body like a busy little helper with a few key jobs:

Imagine homocysteine as a villain in your heart health story. TMG acts like a superhero by helping to keep homocysteine levels in check. How? TMG donates a methyl group, a tiny but important molecule, to homocysteine, transforming it back into a harmless amino acid called methionine. This helps prevent homocysteine from causing problems with your heart and brain.


The Water Warden

TMG plays a vital role in keeping your cells happy and healthy by acting as an osmolyte. Osmolytes are like tiny sponges that help regulate the water balance inside your cells. This ensures your cells stay plump and function properly. Think of it like keeping your car tires at the right air pressure – TMG helps maintain the perfect pressure within your cells.


The Methylation Maestro

Methylation is a crucial process in your body that affects everything from DNA production to energy levels. TMG, as you might guess from its name (trimethylglycine), has three methyl groups it can donate. By donating these methyl groups, TMG helps keep the methylation process running smoothly, supporting various important functions in your body.

So, there you have it! TMG tackles homocysteine, keeps your cells hydrated, and supports methylation – all contributing to your overall well-being.



TMG (trimethylglycine) is a naturally occurring compound that offers potential health benefits. It helps regulate homocysteine levels, which are linked to heart health. TMG may also improve athletic performance and blood sugar control, but more research is needed. TMG supplements can cause side effects like digestive issues, so start with a low dose and talk to your doctor before taking them. You can also get TMG from foods like spinach, quinoa, and beets.